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human alpha-lactalbumin
- Development stage
- Unknown
- Lead developer
- Hamlet Biopharma
- Modality
- Recombinant Proteins and Enzymes, Peptides
01
Overview
Human alpha-lactalbumin is a naturally occurring milk protein that exhibits potent anti-tumor activity when complexed with oleic acid, a form known as HAMLET (Human alpha-lactalbumin made lethal to tumor cells). A synthetic drug candidate, Alpha1H (Alpha1-oleate), which consists of the N-terminal 39 amino acids of the protein complexed with oleic acid, is currently under clinical development. The drug selectively targets malignant cells, inducing apoptosis and inhibiting the expression of cancer-related genes while maintaining a high safety profile for healthy tissues. It has received FDA Fast Track designation for the treatment of non-muscle invasive bladder cancer and has demonstrated significant tumor reduction in Phase II clinical trials. Beyond its therapeutic potential in oncology, human alpha-lactalbumin is also utilized in infant nutrition and functional foods.
- Other names
- hLAHAMLETHuman alpha-lactalbumin made lethal to tumor cells
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