human amnion-derived mesenchymal progenitor cell exosomes

Human amnion-derived mesenchymal progenitor cell exosomes are nanoscale extracellular vesicles, typically 30-150 nm in diameter, secreted by human amnion-derived mesenchymal stem cells (hAMSCs). These hAMSCs are multipotent progenitor cells isolated from the human amniotic tissue of discarded placentas, offering advantages such as self-renewal potential and low immunogenicity. Exosomes act as crucial mediators of cell-to-cell communication by carrying a diverse cargo of proteins, lipids, messenger RNAs, microRNAs, and long non-coding RNAs. Upon delivery to target cells via paracrine signaling, these exosomes exert various therapeutic effects, including immunomodulation, anti-inflammatory actions, pro-regenerative capabilities, and promotion of angiogenesis. They have demonstrated potential in preclinical studies for conditions such as diabetic wound healing, preeclampsia (by enhancing trophoblast survival and autophagy), idiopathic pulmonary fibrosis, bronchopulmonary dysplasia, other lung diseases, liver and kidney fibrosis, asthma, stroke, and neurodegenerative diseases like Alzheimer's disease. Their 'off-the-shelf' potential, stability, and biocompatibility make them an attractive therapeutic modality for tissue repair and disease treatment.

Other names

human amnion-derived mesenchymal stem cell exosomeshAMSC-Exosamnion-derived mesenchymal stem cell exosomesAD-MSC-Exosamnion-derived exosomes