human amniotic epithelial stem cells

Human amniotic epithelial stem cells (hAECs or hAESCs) are a population of pluripotent-like stem cells derived from the innermost layer of the human placenta (the amnion). They possess embryonic stem cell-like proliferation and differentiation capabilities as well as adult stem cell-like immunomodulatory properties. These cells are notable for their low immunogenicity, non-tumorigenicity, and ability to differentiate into all three germ layers. Their mechanism of action is primarily through paracrine signaling and immunomodulation—secreting factors that suppress inflammation, promote tissue repair, inhibit T lymphocyte activation/proliferation, and modulate cytokine environments. Human amniotic epithelial stem cells have been investigated in preclinical models and early clinical trials for a wide range of diseases including neurological disorders (such as Parkinson’s disease), autoimmune diseases (systemic lupus erythematosus, Hashimoto’s thyroiditis), diabetes mellitus, liver injury/failure, lung injury/fibrosis, acute kidney failure/injury, wound healing/tissue repair (including ocular surface disease), spinal cord injury, intrauterine adhesions/infertility conditions such as primary ovarian insufficiency/premature ovarian failure. They are considered promising due to easy isolation from placental tissues after birth without ethical controversy[1][2][3][4][5][6][7][8].

Other names

human amniotic epithelial cellshAECshAESCs