human amniotic fluid derived exosomes

Human amniotic fluid derived exosomes are nanosized extracellular vesicles isolated directly from human amniotic fluid. These vesicles carry a cargo of proteins, lipids, nucleic acids, and other bioactive molecules reflective of their cell of origin. They have demonstrated potent immunomodulatory and regenerative properties in preclinical studies. Mechanistically, they suppress T cell proliferation and activation as well as pro-inflammatory cytokine release by immune cells[1]. In animal models and early clinical reports, they have shown the ability to promote tissue repair (including bone and cartilage), modulate inflammatory responses (notably by inducing an anti-inflammatory transition in microglia), and alleviate neuropathic pain[2][3][5]. Their advantages over parent stem cells include enhanced stability, reduced immunogenicity, the ability to cross biological barriers more easily, and a lower risk profile for adverse reactions[3].

Other names

human amniotic fluid-derived exosomesAF-ExosAF-EVsamniotic-derived exosomes