Human CD40 Ligand mRNA

Human CD40 Ligand mRNA (huCD40L mRNA) refers to messenger RNA that encodes the human CD40 ligand (CD40L) protein. CD40L is a crucial co-stimulatory molecule belonging to the TNF superfamily, primarily expressed on activated T cells and platelets, which interacts with the CD40 receptor found on antigen-presenting cells (APCs) like B cells and dendritic cells. The delivery of huCD40L mRNA into cells, often via electroporation, leads to the expression of the CD40L protein on the cell surface. This expression then activates CD40 on APCs, enhancing immune responses, including T cell activation, proliferation, and differentiation, and promoting anti-tumor activity. This therapeutic approach is being investigated in various applications, particularly in cancer immunotherapy, where it can be incorporated into dendritic cell-based vaccines (e.g., TriMixDC-MEL) or engineered into CAR-T cells to improve their efficacy and overcome antigen-negative tumor escape. It also serves as a molecular adjuvant in vaccine development, such as in DNA vaccines for infectious diseases like SARS-CoV-2, to boost immune responses. While not a standalone drug product, huCD40L mRNA is a key component in several investigational mRNA-based immunotherapies and vaccines.

Other names

CD40L mRNACD-40L mRNACD 40L mRNACD40 ligand mRNACD-40 ligand mRNACD 40 ligand mRNA