human chorionic gonadotropin + GnRH agonist

Human chorionic gonadotropin + GnRH agonist is a combination pharmacological regimen used as a 'dual trigger' for final oocyte maturation in assisted reproductive technology (ART). This protocol, specifically studied by Embryolab Fertility Clinic, involves the administration of hCG alongside a GnRH agonist to induce ovulation. hCG serves as a long-acting analog of Luteinizing Hormone (LH), binding to the LH/hCG receptor to promote oocyte maturation and luteinization. The GnRH agonist component triggers a 'flare' effect, causing the pituitary gland to release endogenous LH and Follicle-Stimulating Hormone (FSH). This dual approach aims to more closely replicate the natural mid-cycle gonadotropin surge compared to hCG alone, potentially improving maturation rates and embryo quality in patients with a history of suboptimal response to single-agent triggers.

Other names

Dual triggerhCG + GnRH-aDual trigger (hCG + GnRH agonist)