Drug intelligence / Profile preview

human cytomegalovirus immunoglobulin

Development stage
Approved
Lead developer
Biotest
Modality
Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

CMV Ig (cytomegalovirus immunoglobulin) is a purified, sterile, plasma-derived hyperimmune globulin preparation containing high titers of immunoglobulin G (IgG) antibodies directed against cytomegalovirus (CMV). Derived from pooled human plasma of donors selected for high anti-CMV antibody levels, CMV Ig provides immediate passive immunity to prevent or attenuate CMV infection and disease. It is primarily indicated for the prophylaxis of CMV disease in high-risk solid organ transplant recipients (such as kidney, liver, lung, pancreas, and heart transplants) and bone marrow transplant recipients, often used in combination with antiviral therapies like ganciclovir. It is also utilized as an adjunctive treatment for established, severe CMV infections, such as CMV pneumonitis.

Brand names
CMV Immunoglobulin-VFCytoGamCytotectMegalotectNeocytotect
Other names
CMV IgCMV-IGCMV-IGIVCMV-IVIgCMVIGcytomegalovirus immune globulincytomegalovirus immune globulin intravenous humancytomegalovirus immunoglobulinhuman cytomegalovirus immune globulinhuman cytomegalovirus immunoglobulin
02

Targets

C1Q (Complement C1q)FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)HCMV Pentamer (HCMV pentameric glycoprotein complex)Human cytomegalovirus glycoprotein H/glycoprotein L/glycoprotein O complex (HCMV gH/gL/gO)Human cytomegalovirus glycoprotein M/glycoprotein N complexgB (Human cytomegalovirus glycoprotein B)

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