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Drug intelligence / Profile preview
human embryonic stem cell-derived mesenchymal stem cells
- Development stage
- Unknown
- Lead developer
- ImStem Biotechnology
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous, Intrathecal, Intraperitoneal, Inhalation, Intrabronchial, Intra-arterial, Intramuscular
01
Overview
Human embryonic stem cell-derived mesenchymal stem cells (hES-MSCs) are a specialized population of mesenchymal stem cells generated through the directed differentiation of pluripotent human embryonic stem cells. Unlike adult MSCs derived from bone marrow or adipose tissue, hES-MSCs offer a more scalable and highly standardized "off-the-shelf" therapeutic source with superior proliferative capacity and consistent immunomodulatory properties. These cells function primarily through the secretion of anti-inflammatory cytokines and trophic factors, which modulate T-cell responses and promote tissue repair. They are being investigated for a variety of conditions, including autoimmune diseases like multiple sclerosis and systemic lupus erythematosus, as well as regenerative applications such as primary ovarian insufficiency.
- Other names
- hES-MSCshESC-MSCshuman embryonic stem cell derived mesenchymal stem cell-like cellshES-MSC
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