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human hookworm vaccine
- Development stage
- Unknown
- Lead developer
- Sabin Vaccine Institute
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The **human hookworm vaccine** is an investigational bivalent recombinant protein-subunit vaccine for prevention of *Necator americanus* hookworm infection and its consequences, including intestinal blood loss and iron-deficiency anemia. It contains recombinant *N. americanus* glutathione S-transferase-1 and catalytically inactive *N. americanus* aspartic protease-1 M74, two parasite blood-feeding-pathway enzymes. Administered intramuscularly with Alhydrogel and, in studied formulations, a synthetic Toll-like receptor agonist adjuvant, it is intended to elicit antigen-specific antibodies that impair hookworm blood digestion, development, and survival. The program has been developed by the Sabin Vaccine Institute and collaborators for use in endemic populations, particularly children.
- Other names
- bivalent human hookworm vaccine
02
Targets
Na-GST-1 (Glutathione S-transferase 1 from Necator americanus)Na-APR-1 (Necator americanus aspartic protease 1)
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