Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
human hookworm vaccine
- Development stage
- Unknown
- Lead developer
- Sabin Vaccine Institute
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
The **human hookworm vaccine** is an investigational bivalent recombinant protein-subunit vaccine for prevention of *Necator americanus* hookworm infection and its consequences, including intestinal blood loss and iron-deficiency anemia. It contains recombinant *N. americanus* glutathione S-transferase-1 and catalytically inactive *N. americanus* aspartic protease-1 M74, two parasite blood-feeding-pathway enzymes. Administered intramuscularly with Alhydrogel and, in studied formulations, a synthetic Toll-like receptor agonist adjuvant, it is intended to elicit antigen-specific antibodies that impair hookworm blood digestion, development, and survival. The program has been developed by the Sabin Vaccine Institute and collaborators for use in endemic populations, particularly children.
- Other names
- bivalent human hookworm vaccine
02
Targets
Na-APR-1 (Necator americanus aspartic protease 1)Na-GST-1 (Glutathione S-transferase 1 from Necator americanus)
Beyond the preview
Go deeper on human hookworm vaccine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on human hookworm vaccine.