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human IgG monoclonal antibodies against SFTS virus
- Development stage
- Preclinical
- Lead developer
- U.S. Military HIV Research Program
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
01
Overview
Human IgG monoclonal antibodies against SFTS virus (Severe Fever with Thrombocytopenia Syndrome virus, also known as Dabie bandavirus) are therapeutic candidates developed to treat or prevent SFTS infections [6643]. Generated using humanized DRAGA mice (which possess a functional human immune system) immunized with a DNA vaccine encoding the M segment of the virus and boosted with recombinant protein, these human monoclonal antibodies (hmAbs) specifically target the SFTS virus envelope glycoprotein Gn [6643]. By binding to glycoprotein Gn, the antibodies neutralize the virus, inhibiting viral attachment and entry into host cells. Currently, these antibodies are in preclinical development, with no FDA-approved vaccines or therapeutics yet available for SFTS [6643].
- Other names
- human IgG monoclonal antibodies against Dabie bandavirushuman IgG monoclonal antibodies against Severe Fever with Thrombocytopenia Syndrome virushuman monoclonal antibodies against SFTS-glycoprotein (Gn)human monoclonal antibodies against SFTSV-Gn
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