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human-induced pluripotent stem cell-derived platelets
- Development stage
- Unknown
- Lead developer
- Megakaryon
- Modality
- iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Human-induced pluripotent stem cell-derived platelets (hiPSC-platelets) are a biologic cell therapy modality in which functional platelets are generated ex vivo from human induced pluripotent stem cells (hiPSCs) via differentiation through megakaryocytes. They are being developed as a renewable, donor-independent alternative to conventional blood-banked platelets, which are subject to supply shortages and risk of alloimmune refractoriness. The most prominent candidate, MEG-002, was evaluated in the first-in-human iPLAT1 trial for autologous transfusion in aplastic anemia. Other applications include chemotherapy-induced thrombocytopenia in acute leukemia. Preclinical research has also explored using these platelets as targeted drug-delivery vehicles for oncology therapeutics.
- Other names
- hiPSC-plateletsiPSC-derived plateletshuman induced pluripotent stem cell-derived platelets
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