human insulin isophane

Gensulin N is an intermediate-acting recombinant human insulin (NPH/isophane) developed by BIOTON for the management of diabetes mellitus. It is produced using recombinant DNA technology and formulated as a crystalline suspension with protamine and zinc, which delays its absorption from the subcutaneous injection site, resulting in a prolonged duration of action compared to regular soluble insulin. The drug acts as an agonist at the insulin receptor, stimulating glucose uptake in peripheral tissues such as skeletal muscle and adipose tissue, while simultaneously inhibiting hepatic glucose production. It is typically used to provide basal insulin coverage throughout the day or night.

Brand names

Gensulin N

Other names

NPH insulinIsophane insulinNeutral Protamine Hagedorn insulinHuman insulin isophane