human laminin-111

Human Laminin-111 is a trimeric protein composed of α1, β1, and γ1 chains and is one of the earliest extracellular matrix proteins expressed during embryogenesis. It plays a critical role in basement membrane assembly and supports fundamental cellular processes such as cell adhesion, differentiation, migration, and tissue morphogenesis. Human Laminin-111 has been investigated as a protein replacement therapy for congenital muscular dystrophies—particularly merosin (laminin-alpha2) deficient congenital muscular dystrophy type 1A (LAMA2-CMD)—and Duchenne Muscular Dystrophy. Recombinant forms are produced for research and investigational therapeutic use; they have shown efficacy in preclinical models by improving muscle pathology and function through modulation of cell-matrix interactions. Mechanistically, it acts as an extracellular matrix ligand interacting with integrins (notably α3β1-integrins) to regulate cellular signaling pathways involved in tissue repair and regeneration[4][6][10]. It is also widely used as a substrate for stem cell culture and tissue engineering applications[6][8].

Other names

Laminin-111 (human)Lm111Lm-111Lm 111iMatrix-111iMatrix111iMatrix 111