human pancreatic islets

Human pancreatic islets are an allogeneic cell therapy product consisting of purified clusters of endocrine cells (including beta, alpha, and delta cells) isolated from deceased donor pancreata. Developed and investigated by Ohio State University, this therapy is intended for patients with type 1 diabetes mellitus who experience severe hypoglycemia or have undergone kidney transplantation. The islets are transplanted via infusion into the recipient's hepatic portal vein, where they engraft in the liver and function as a biological glucose-sensing and insulin-releasing system. By restoring endogenous insulin production, the treatment aims to achieve insulin independence, stabilize blood glucose levels, and reduce the long-term complications of diabetes.

Other names

Human Pancreatic IsletsIslet AllograftAllogeneic Islets