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human papillomavirus type 16 DNA therapeutic vaccine
- Development stage
- Preclinical
- Lead developer
- Zhuoyi Biological
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Human papillomavirus type 16 DNA therapeutic vaccine is a preclinical DNA-based immunotherapy being developed by Zhuoyi Biological for the treatment of HPV16-associated infections and related lesions. Unlike prophylactic vaccines that prevent infection by inducing neutralizing antibodies, this therapeutic vaccine is designed to stimulate a cellular immune response, specifically targeting the E6 and E7 oncoproteins of HPV type 16. By delivering DNA plasmids encoding these viral antigens into host cells, the vaccine promotes the activation of cytotoxic T lymphocytes (CTLs) to identify and eliminate HPV-infected or transformed cells, potentially treating persistent infections or preventing progression to cervical cancer.
- Other names
- HPV16 DNA therapeutic vaccineHPV-16 DNA therapeutic vaccineHPV 16 DNA therapeutic vaccine人乳头瘤病毒 16 型 DNA治疗性疫苗
02
Targets
HPV16 E6 oncoproteinHPV16 E7 (Human papillomavirus 16 E7 protein)
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