human papillomavirus type 18 L1 capsid protein antigen

Human papillomavirus type 18 L1 capsid protein antigen is a recombinant viral protein that forms the major structural component of the virus-like particles (VLPs) used in prophylactic vaccines against human papillomavirus (HPV). It is produced using recombinant DNA technology in yeast (*Saccharomyces cerevisiae*) or insect cells and self assembles into VLPs that mimic the native virus structure but lack viral DNA. These VLPs elicit a strong immune response by inducing neutralizing antibodies against oncogenic high-risk types of HPVs—primarily types 16 and 18—which are associated with cervical cancer and other anogenital cancers. The antigen is a key active ingredient in approved vaccines such as Gardasil (quadrivalent/nonavalent) and Cervarix (bivalent), which are indicated for prevention of diseases caused by infection with specific high-risk HPVs[1][7][8]. The mechanism of action involves induction of serotype-specific immunity through presentation of conformational epitopes on the surface of VLPs.

Brand names

GardasilGardasil 9Gardasil9Gardasil-9Cervarix

Other names

HPV-18 L1 proteinHPV18 L1 proteinHPV 18 L1 proteinHPV-18 Shell ProteinHPV18 Shell ProteinHPV 18 Shell ProteinHPV-18 Capsid ProteinHPV18 Capsid ProteinHPV 18 Capsid ProteinHPV-18 Coat ProteinHPV18 Coat ProteinHPV 18 Coat ProteinHPV-18 Major Capsid ProteinHPV18 Major Capsid ProteinHPV 18 Major Capsid ProteinHPV-18 Structural ProteinHPV18 Structural ProteinHPV 18 Structural ProteinHPV-18 Viral Capsid Protein L1HPV18 Viral Capsid Protein L1HPV 18 Viral Capsid Protein L1HPV-18 Outer Capsid ProteinHPV18 Outer Capsid ProteinHPV 18 Outer Capsid ProteinHPV-18 Shell Component L1HPV18 Shell Component L1HPV 18 Shell Component L1HPV-18 Capsomer Protein L1HPV18 Capsomer Protein L1HPV 18 Capsomer Protein L1HPV-18 Surface Antigen L1HPV18 Surface Antigen L1HPV 18 Surface Antigen L1