human papillomavirus type 45 L1 protein virus-like particle

**Human papillomavirus type 45 L1 protein virus-like particle** is a prophylactic HPV vaccine antigen consisting of self-assembled virus-like particles formed from the major capsid protein L1 of HPV type 45. As a noninfectious VLP immunogen, it is designed to mimic the native HPV45 virion and induce type-specific neutralizing antibody responses that can prevent infection and downstream HPV45-associated neoplasia; it does not contain viral genome and is not a therapeutic antiviral agent for established infection. The specific entry here refers to the monovalent HPV45 L1 VLP antigen itself rather than a marketed multivalent product. Based on the provided context, Institut Gustave Roussy is associated with clinical development in HPV-related high-grade squamous intraepithelial lesion settings, but the exact monovalent HPV45 L1 VLP appears more accurately to be a vaccine component or investigational antigen than a distinct approved standalone medicine.

Brand names

Gardasil 9Gardasil9Gardasil-9

Other names

HPV45 L1 virus-like particleHPV-45 L1 virus-like particleHPV 45 L1 virus-like particlehuman papillomavirus 45 L1 virus-like particlehuman papillomavirus type 45 L1 VLP