Drug intelligence / Profile preview

human placental hydrolysate

Development stage
Unknown
Lead developer
Japan Bio Products
Modality
Peptides
Administration
Intradermal, Intramuscular, Intravenous, Subcutaneous
01

Overview

Human placental hydrolysate is a standardized, pharmaceutical-grade biological preparation derived from healthy human donor placentas. It is produced through enzymatic hydrolysis (typically using pepsin and hydrochloric acid) followed by rigorous sterilization and filtration processes to ensure safety and eliminate viral or bacterial pathogens. The resulting extract is a complex, chemically heterogeneous mixture containing low-molecular-weight peptides, amino acids, nucleotides, vitamins, minerals, and trace growth factors such as hepatocyte growth factor (HGF) and insulin-like growth factor 1 (IGF-1). It is widely utilized in East Asia and Russia for its hepatoprotective, immunomodulatory, anti-inflammatory, and tissue-regenerative properties. Standardized formulations are marketed under several brand names, including Laennec (approved for improving liver function in chronic liver disease) and Melsmon (approved for menopausal disorders and milk secretion deficiency). Additionally, it is investigated for various off-label and clinical-stage indications, including chronic fatigue syndrome, musculoskeletal pain, and neurodegenerative conditions such as multiple sclerosis.

Brand names
CuracenLaennecMelsmonPlagenticUnicenta
Other names
Hominis placenta extractHominis placenta hydrolysateHominis placental extractHominis placental hydrolysatehuman placenta extracthuman placental extractwater soluble human placental hydrolysate
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)AR (Adrenergic receptors)CASP1 (Caspase-1)CASP3 (Caspase-3)CASP4 (Caspase-4)ESR1 (ERα)ITGB1 (Integrin beta-1)KEAP1 (Kelch-like ECH-associated protein 1)MEKNFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NF-κBPTPN11 (Tyrosine-protein phosphatase non-receptor type 11)PTPN6 (Protein tyrosine phosphatase non-receptor type 6)STING (Stimulator of interferon genes protein)TBK1 (TANK binding kinase 1)TLR4 (Toll-like receptor 4)TNFA (Tumor necrosis factor alpha (soluble))TP53 (Cellular Tumor Antigen p53 R175H)

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