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Human rabies immunoglobulin (HRIG) is a plasma-derived biologic developed by Tonglu Biopharmaceutical for the post-exposure prophylaxis of rabies. It consists of a sterile solution of antirabies antibodies concentrated from the plasma of hyperimmunized human donors. HRIG provides immediate passive immunity by binding to and neutralizing the rabies virus at the site of exposure, preventing the virus from attaching to and entering nerve cells. This treatment is critical during the window before a patient's active immune response is triggered by the rabies vaccine. It is typically administered via local infiltration around the wound and intramuscular injection.
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