human relaxin-1 sulfoxide

Human relaxin-1 sulfoxide is a synthetic peptide analog of the endogenous human relaxin-1 (H1) hormone, featuring the oxidation of methionine residues to sulfoxides. Developed by Relaxera, this peptide is designed to act as an agonist at the relaxin-family peptide receptors RXFP1 and RXFP2. While human relaxin-2 is the primary circulating form in humans, relaxin-1 is a paralog with similar receptor affinity and tissue-specific expression. The sulfoxide modification is often studied to understand the metabolic stability and potency of relaxin peptides, as methionine oxidation is a common post-translational or degradative change that can influence biological activity. The compound is currently in preclinical development for potential applications in conditions where relaxin signaling is therapeutic, such as fibrotic disorders, cardiovascular health, or reproductive medicine.

Other names

Met(O)-human relaxin-1oxidized human relaxin-1human relaxin-1 sulfoxide-Relaxera-RXFP1-RXFP2-synthetic peptide