human umbilical cord blood cells expressing vascular endothelial growth factor and L1 cell adhesion molecule

**Human umbilical cord blood cells expressing vascular endothelial growth factor and L1 cell adhesion molecule** are an unbranded preclinical gene-modified cell therapy investigated for amyotrophic lateral sclerosis. Human umbilical cord blood cells were electroporated with non-viral plasmids encoding human VEGF165 and mouse neural L1CAM. The engineered cells were intended to deliver VEGF and L1CAM within neurodegenerating tissue: L1CAM was intended to support cell homing and persistence, while VEGF was intended to promote endothelial differentiation, angiogenesis, and secretion of neurotrophic factors. In G93A-SOD1 ALS-model mice, transplanted human cells were detected in spinal-cord vascular structures for more than three months and showed an endothelial rather than neuronal phenotype. The work was associated with Kazan State Medical University and supported by Asklepios-Med. ([sciencedirect.com](https://www.sciencedirect.com/science/article/abs/pii/S0197018608001575))

Other names

human umbilical cord blood cells transfected with VEGF and L1CAMVEGF and L1CAM-transfected human umbilical cord blood cells