human umbilical cord matrix stem cells

Human umbilical cord matrix stem cells (UCMSCs or uMSCs) are a type of mesenchymal stem cell derived from the Wharton’s Jelly of the human umbilical cord. These cells are characterized by their robust growth capacity, ability to be clonally expanded and cryopreserved, and expression of typical mesenchymal markers (CD10, CD13, CD29, CD44, CD90; negative for hematopoietic markers such as CD34 and CD45)[1][3][6]. UCMSCs exhibit immunomodulatory properties and secrete various trophic factors including growth factors like IGF1 that support tissue repair and regeneration[2][7]. They have demonstrated potential in preclinical models for treating neurodegenerative diseases (such as Parkinson’s disease), diabetes (type 1 and type 2), osteoarthritis, liver fibrosis, stroke, multiple sclerosis, retinal diseases, myogenic diseases[1][2][3][7]. Their mechanism involves homing to injured tissues where they exert paracrine effects—modulating immune responses and promoting survival/proliferation of local cells via secretion of bioactive molecules. Unlike bone marrow-derived MSCs they can be collected non-invasively after birth in large quantities[3].

Other names

UCMS cellsuMSCshuman umbilical cord mesenchymal stem cellshUC-MSCs