human umbilical cord mesenchymal stem cell-derived exosomes

Human umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSC-Exos) are nanosized extracellular vesicles, typically ranging from 30 to 200 nm in diameter, secreted by mesenchymal stem cells harvested from human umbilical cord tissue. As a cell-free therapeutic platform, these exosomes carry a complex cargo of bioactive molecules, including microRNAs (e.g., miR-129-5p, miR-19a), long non-coding RNAs (e.g., lncRNA-9969), and proteins (e.g., TGF-beta 1), which mediate intercellular communication and tissue regeneration. The therapeutic mechanism involves the modulation of multiple signaling pathways, such as the activation of the SIRT1-FXR axis to inhibit NLRP3 inflammasome activity in macrophages and the targeting of ACSL4 to suppress ferroptosis and lipid peroxidation. hUC-MSC-Exos are currently being investigated in numerous clinical trials for diverse indications, including inflammatory bowel disease, autoimmune encephalitis, vitiligo, dry eye disease, and neurodegenerative disorders, offering a potential alternative to stem cell transplantation with reduced risks of immunogenicity and tumorigenicity.

Other names

脐带间充质干细胞外泌体human umbilical cord mesenchymal stem cell-derived exosomehUC-MSC-derived exosomesumbilical cord MSC-derived exosomes