Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
human umbilical cord mesenchymal stem cell-derived exosomes (The First Affiliated Hospital of Xinxiang Medical College)
- Development stage
- Phase 1
- Lead developer
- ECHO Biotech
- Modality
- Small Molecules, Recombinant Proteins and Enzymes, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intranasal
01
Overview
Human umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSC-Exos) are nano-sized extracellular vesicles secreted by mesenchymal stem cells of the umbilical cord. These vesicles carry a bioactive cargo of proteins, lipids, and nucleic acids that mediate potent anti-inflammatory and immunomodulatory effects, promoting tissue repair and regeneration. In clinical development, specifically by the First Affiliated Hospital of Xinxiang Medical College, these exosomes are being evaluated as the primary biological component of a triple-combination thermosensitive gel nasal spray for the treatment of chronic rhinosinusitis without nasal polyps (CRSsNP). This investigational product is co-formulated with mupirocin, an antibiotic targeting *Staphylococcus aureus*, and DNase I, an enzyme that degrades extracellular DNA in bacterial biofilms. The thermosensitive gel formulation allows the spray to transition into a soft gel at body temperature, ensuring prolonged contact and sustained release of the active ingredients within the sinonasal cavity to reduce infection, clear mucus, and improve symptoms.
- Other names
- umbilical cord mesenchymal stem cell exosomeshUC-MSC-derived exosomes
02
Targets
NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)
Beyond the preview
Go deeper on human umbilical cord mesenchymal stem cell-derived exosomes (The First Affiliated Hospital of Xinxiang Medical College).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on human umbilical cord mesenchymal stem cell-derived exosomes (The First Affiliated Hospital of Xinxiang Medical College).