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human umbilical cord mesenchymal stem cell-derived small extracellular vesicle eye drops
- Development stage
- Unknown
- Lead developer
- First Affiliated Hospital of Xiamen University
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Cell Therapies
- Administration
- Ophthalmic
01
Overview
Human umbilical cord mesenchymal stem cell-derived small extracellular vesicle (hUC-MSC-sEV) eye drops is an investigational biologic therapy being developed for the treatment of dry eye disease (DED). The product consists of small extracellular vesicles (40–160 nm), including exosomes, harvested from human umbilical cord mesenchymal stem cells. These vesicles carry a bioactive cargo of microRNAs (such as miR-21, miR-146a, and miR-100-5p), proteins, and lipids that exert immunomodulatory and regenerative effects on the ocular surface. The mechanism of action involves the suppression of inflammatory signaling pathways, including IRAK1/TAB2/NF-κB and PTEN/PI3K/Akt, and the promotion of M2 macrophage polarization and T regulatory cell induction. It is currently being evaluated in early-phase clinical trials by The First Affiliated Hospital of Xiamen University for both non-Sjögren's and Sjögren's syndrome-associated dry eye.
- Other names
- human umbilical cord mesenchymal stem cell-derived small extracellular vesicle (hUC-MSC-sEV) eye dropshuman mesenchymal stem cell small extracellular vesicle eye drops
02
Targets
NF-κBAKT (RAC-alpha serine/threonine-protein kinase)IL-6R (Interleukin-6 receptor subunit alpha)TAB2PI3K (Phosphoinositide-3-kinase regulatory subunit 6)IRAK1 (Interleukin-1 receptor-associated kinase 1)PTEN (Phosphatase and tensin homolog deleted on chromosome ten)
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