Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
human umbilical cord mesenchymal stem cell extracellular vesicle-enriched secretome fraction
- Development stage
- Unknown
- Lead developer
- Medizinische Hochschule Hannover
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intracochlear
01
Overview
Human umbilical cord mesenchymal stem cell extracellular vesicle-enriched secretome fraction is an investigational cell-free biologic developed by Medizinische Hochschule Hannover (MHH) for the treatment of sensorineural hearing loss, particularly in patients receiving cochlear implants. This therapeutic fraction is derived from the conditioned medium of human umbilical cord mesenchymal stem cells (hUC-MSCs) and is specifically processed to concentrate extracellular vesicles (EVs), which encapsulate a potent mixture of neurotrophic factors, anti-inflammatory cytokines, and microRNAs. The primary therapeutic goal is to protect spiral ganglion neurons (SGNs) from apoptosis and to modulate the inflammatory and fibrotic response triggered by the insertion of cochlear implant electrodes. By preserving the neural population and improving the electrode-nerve interface, the secretome fraction aims to enhance auditory outcomes and preserve residual hearing in implanted patients.
- Other names
- hUC-MSC secretomeumbilical cord mesenchymal stem cell-derived extracellular vesicles
02
Targets
GFRA1 (Glial cell line-derived neurotrophic factor family receptor alpha 1)NTRK2 (Tropomyosin-related kinase receptor type B)
Beyond the preview
Go deeper on human umbilical cord mesenchymal stem cell extracellular vesicle-enriched secretome fraction.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on human umbilical cord mesenchymal stem cell extracellular vesicle-enriched secretome fraction.