human umbilical cord mesenchymal stem cells

Human umbilical cord mesenchymal stem cells (hUC-MSCs) are multipotent stromal cells derived from the Wharton's jelly of the human umbilical cord. They are characterized by high proliferative capacity, low immunogenicity, and potent immunomodulatory properties, making them a versatile platform for regenerative medicine. hUC-MSCs exert their therapeutic effects primarily through paracrine signaling, secreting a variety of anti-inflammatory and regenerative factors including tumor necrosis factor-inducible gene 6 protein (TSG-6), prostaglandin E2 (PGE2), indoleamine 2,3-dioxygenase (IDO), and transforming growth factor-beta (TGF-β). These factors modulate the immune environment by inhibiting M1 macrophage polarization, promoting the expansion of regulatory T cells (Tregs), and suppressing Th17 cell activity. Clinical development of hUC-MSCs is extensive, with ongoing investigations in autoimmune diseases (Crohn's disease, systemic lupus erythematosus, psoriasis), neurological disorders (cerebral palsy, Parkinson's disease, acute ischemic stroke), and degenerative conditions (osteoarthritis, liver cirrhosis). While generally therapeutic, some preclinical evidence suggests they may promote tumor progression in specific environments such as hepatocellular carcinoma.

Brand names

Chondrocell-EXCyto-MSC

Other names

hUC-MSCsUC-MSCsumbilical cord-derived mesenchymal stem cellsWharton's jelly-derived mesenchymal stem cells