Drug intelligence / Profile preview

humanin

Development stage
Unknown
Modality
Peptides
Administration
Subcutaneous, Intravenous, Intramuscular, Intranasal, Intraperitoneal, Intracerebroventricular, Oral
01

Overview

Humanin is an endogenous mitochondrial-derived peptide with reported cytoprotective, neuroprotective, and metabolic effects in preclinical models. It has been studied as a peptide biologic that can improve insulin sensitivity, modulate cellular stress responses, and promote cell survival, but it has not been developed into an approved therapeutic product. Publicly available information indicates that humanin and humanin analogs remain largely research-stage agents, with no active interventional clinical development as a drug; humanin has also appeared in clinical research contexts as a biomarker rather than as an administered therapy. A key limitation to therapeutic development has been its pharmacokinetic profile.

Other names
humaninHN
02

Targets

FPR3 (Formyl peptide receptor 3)IGFBP3 (Insulin-like growth factor-binding protein 3)Aβ (Amyloid-beta peptides and aggregates)BAX (Apoptosis regulator BAX)tBID (Truncated BID)TRIM11 (Tripartite motif containing 11)IL27RA (Interleukin-27 receptor subunit alpha)

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