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Humanized JAA-F11
- Development stage
- Preclinical
- Lead developer
- University at Buffalo
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Humanized JAA-F11 (hJAA-F11) is a humanized monoclonal antibody (IgG1) targeting the tumor-associated Thomsen-Friedenreich glycoantigen (TF-Ag-alpha). Developed by For-Robin (a spinout from the University at Buffalo), hJAA-F11 is designed to treat TF-Ag-expressing carcinomas, particularly breast cancer (including triple-negative breast cancer) and lung cancer. It works by directly binding to TF-Ag-alpha on cancer cells, blocking tumor cell adhesion and metastasis, and mediating antibody-dependent cellular cytotoxicity (ADCC). Additionally, hJAA-F11 is being developed as an antibody-drug conjugate (ADC) payload delivery vehicle (e.g., conjugated to maytansine as hJAA-F11-DM1) and as a radiolabeled diagnostic imaging agent (124I-hJAA-F11) for detecting metastasis.
- Other names
- Humanized JAA-F11 for direct antibody therapy of Breast CancerhJAA-F11hJAA-F-11hJAA-F 11hJAA-F11 H2aL2ahJAA-F-11 H2aL2ahJAA-F 11 H2aL2ahJAA-F11 H3L3hJAA-F-11 H3L3hJAA-F 11 H3L3hJAA_F11
02
Targets
TF antigen (Thomsen-Friedenreich antigen)
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