humulus lupulus extract

Humulus lupulus extract, commonly known as hops extract, is a botanical ingredient derived from the female flowers (cones) of the hop plant. In the context of oral care, it is being developed by Procter & Gamble as an active component in dentifrice (toothpaste) formulations for the treatment and prevention of gingivitis. The extract contains bioactive compounds, primarily alpha-acids (humulones) and beta-acids (lupulones), which exhibit potent antimicrobial activity against key oral pathogens such as *Porphyromonas gingivalis*. Additionally, hops extract possesses anti-inflammatory properties, potentially reducing gingival inflammation by inhibiting pro-inflammatory mediators. Clinical evaluations have focused on its efficacy when formulated with fluoride sources to improve overall gingival health compared to standard stannous fluoride or sodium monofluorophosphate controls.

Other names

hops extracthop extract