Drug intelligence / Profile preview

Huo Xue Jie Du Tang

Development stage
Unknown
Lead developer
China-Japan Friendship Hospital
Modality
Small Molecules
Administration
Oral
01

Overview

Huo Xue Jie Du Tang (HXJDT) is a Traditional Chinese Medicine (TCM) decoction developed by the China-Japan Friendship Hospital, specifically for the treatment of plaque psoriasis (psoriasis vulgaris). The formula is designed based on the TCM theory of blood stasis and toxin-heat, aiming to promote blood circulation and clear heat-toxins. It typically contains a combination of herbs such as *Radix Rehmanniae*, *Rhizoma Smilacis Glabrae*, *Radix Salviae Miltiorrhizae*, and *Radix Paeoniae Rubra*. Research suggests it modulates the immune response by inhibiting the IL-23/IL-17 axis, reducing the expression of inflammatory cytokines like TNF-α and IL-6, and regulating the proliferation and differentiation of keratinocytes. It is primarily used as a hospital-made preparation in clinical practice.

Other names
Huoxue Jiedu DecoctionHXJDT
02

Targets

IL-6 (Interleukin 6)IL-23 (Interleukin-23)TNFA (Tumor necrosis factor alpha (soluble))IL-17A (Interleukin-17A)IL22 (Interleukin 22)

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