Drug intelligence / Profile preview

Huoluo Pills

Development stage
Unknown
Lead developer
Beijing Tong Ren Tang
Modality
Small Molecules
Administration
Oral
01

Overview

Huoluo Pills is a traditional Chinese medicine (TCM) formulation primarily used for the treatment of rheumatoid arthritis (RA) and other musculoskeletal disorders characterized by 'Wind-Damp' or 'Cold-Damp' obstruction according to TCM theory. The formulation typically consists of several herbal and animal-derived ingredients, including processed *Radix Aconiti* (Chuan Wu), *Radix Aconiti Kusnezoffii* (Cao Wu), *Arisaema Cum Bile* (Dan Nan Xing), *Lumbricus* (Di Long), *Olibanum* (Ru Xiang), and *Myrrha* (Mo Yao). Huoluo Pills are designed to dispel wind, eliminate dampness, resolve phlegm, and unblock the body's collaterals to alleviate pain and joint stiffness. Pharmacologically, the constituents of the pills have been shown to exert anti-inflammatory, analgesic, and immunomodulatory effects by suppressing the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, as well as inhibiting the activity of enzymes like COX-2.

Brand names
Huoluo PillsXiao Huoluo WanXiao Huo Luo Dan
Other names
Minor Huoluo PillsMinor Activator PillsHuoluo WanXiao Huoluo Pills
02

Targets

IL1B (Interleukin-1 beta)STAT3 (Signal Transducer and Activator of Transcription 3)VEGFA (Vascular endothelial growth factor A)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TP53 (Cellular Tumor Antigen p53 R175H)HSP90AA1 (Heat shock protein HSP90-alpha)IL-6 (Interleukin 6)

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