Drug intelligence / Profile preview

Huosu Yangwei

Development stage
Unknown
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration
Oral
01

Overview

Huosu Yangwei (HSYW) is a traditional Chinese herbal medicine formula extensively used for the treatment of chronic atrophic gastritis, precancerous gastric lesions, and advanced gastric cancer. It is typically administered as an oral liquid. Pharmacological studies have shown that HSYW can inhibit multiple cytochrome P450 enzymes (CYPs) in human liver preparations and modulate the pharmacokinetics of co-administered drugs such as apatinib by prolonging its plasma half-life and increasing systemic exposure[1][2][3]. Network pharmacology and transcriptomic analyses suggest that HSYW exerts anti-tumor effects by regulating gene expression networks involved in tumor growth inhibition; animal experiments confirm significant tumor suppression in vivo[4][5][7]. The precise active compounds are not fully characterized but include a complex mixture of herbal ingredients.

Brand names
Huosu YangweiHuosu Yangwei oral liquid
Other names
HSYWHuosu-Yangwei formula
02

Targets

PRDM1 (PR domain zinc finger protein 1)SOCS3 (Suppressor of cytokine signaling 3)AKR1C1 (Aldo-keto reductase family 1 member C1)PREX1 (P-Rex1 / PREX1)CST1 (Cystatin-SN)HIV-1 CA/SP1 junction (HIV-1 Gag capsid/spacer peptide 1 junction)HSP (Heat shock proteins)

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