Drug intelligence / Profile preview

Huoxin Pill

Development stage
Phase 4
Lead developer
Yuekang Pharmaceutical
Administration
Oral
01

Overview

Huoxin Pill (活心丸) is a traditional Chinese medicine (TCM) preparation used for the treatment of cardiovascular diseases, primarily coronary heart disease and angina pectoris. [3, 10] It is composed of multiple ingredients including ginseng, red flower, artificial musk, and borneol. [3, 4] The medicine is based on the TCM principle of "tonifying qi and activating blood circulation, warming meridians to unblock vessels". [2, 4] Clinical studies have shown it can improve symptoms of angina, increase coronary blood flow, and enhance cardiac function. [6, 9] It is being investigated in multiple clinical trials for its effects post-percutaneous coronary intervention (PCI) and to explore its underlying molecular mechanisms, which are thought to involve anti-inflammatory pathways like the suppression of TLR4/NF-κB and Wnt/β-catenin signaling. [10, 12, 14] The drug is approved in China and is included in the national medical insurance catalog. [3, 5]

Brand names
Yuekang Huoxin PillYuekang® Huoxinwan
Other names
Huoxinwan活心丸
02

Targets

RELA (Nuclear Factor Kappa B Subunit p65)TLR4 (Toll-like receptor 4)TNFRSF1A (Tumor necrosis factor receptor superfamily member 1A)

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