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huperzine b
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Huperzine B is a naturally occurring alkaloid derived from the Chinese club moss Huperzia serrata. It is structurally related to huperzine A and functions as a reversible acetylcholinesterase inhibitor, increasing levels of acetylcholine in the brain. This mechanism is similar to that of pharmaceutical drugs like galantamine and donepezil, which are used for Alzheimer's disease. Huperzine B has been investigated primarily for its potential cognitive-enhancing and neuroprotective effects, including possible use in dementia and other neurological disorders. Clinical trials in China have suggested it may be comparably effective to existing drugs with potentially fewer side effects[1][2][4].
- Other names
- huperzine bHupB
02
Targets
Acetylcholinesterase
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