huprine X

Huprine X is a potent, synthetic hybrid inhibitor of acetylcholinesterase (AChE), designed by merging the structural features of the Alzheimer's drugs tacrine and huperzine A. It exhibits exceptionally high affinity for AChE, acting as a bitopic ligand that interacts with both the catalytic active site and the peripheral anionic site of the enzyme. This dual binding mechanism not only enhances its potency in restoring synaptic acetylcholine levels but also contributes to its ability to inhibit amyloid-beta (Aβ) aggregation, a hallmark of Alzheimer's disease pathology. Developed by researchers at the University of Barcelona, huprine X has served as a lead compound for the development of multi-target directed ligands (MTDLs) aimed at addressing the complex etiology of neurodegenerative disorders. It is widely used in research as a reference compound for potent, reversible cholinergic inhibition.

Other names

3-chloro-9-ethyl-6,7,8,9,10,11-hexahydro-7,11-methanocycloocta[b]quinolin-12-amineHuprine X12-amino-3-chloro-9-ethyl-6,7,8,9,10,11-hexahydro-7,11-methanocycloocta[b]quinoline