Drug intelligence / Profile preview

Huqi San

Development stage
Unknown
Lead developer
Capital Medical University
Modality
Small Molecules
Administration
Oral
01

Overview

Huqi San (HQS) is a Traditional Chinese Medicine (TCM) herbal preparation composed of eight medicinal herbs, including notably *Viscum coloratum* (Hujisheng) and *Astragalus membranaceus* (Huangqi). It is primarily utilized in the context of hepatology and oncology. Preclinical research indicates that HQS can evoke colonic anion secretion by increasing the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) and modulate the expression of various bile transporters, suggesting therapeutic potential for cholestasis and jaundice. Clinically, Huqi San is used as an adjuvant therapy for primary liver cancer (hepatocellular carcinoma), particularly when combined with transarterial chemoembolization (TACE). In this setting, it has been shown to improve T-lymphocyte subsets, enhance immune function, improve quality of life (as measured by KPS scores), and prolong survival in patients.

Other names
HuqisanHQS槲芪散
02

Targets

CFTR (Cystic fibrosis transmembrane conductance regulator)

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