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huRH105-DGN549
- Development stage
- Preclinical
- Lead developer
- AbbVie
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
huRH105-DGN549 is an investigational **anti-endoglin antibody-drug conjugate** developed by ImmunoGen for tumor-vasculature targeting. It combines huRH105, a humanized monoclonal antibody that binds endoglin, with DGN549, an indolinobenzodiazepine DNA-alkylating payload. The conjugate was prepared through lysine-directed antibody conjugation and showed endoglin-specific cytotoxicity in endothelial cells plus modest antitumor activity and therapeutic indices in rat xenograft studies. No INN, marketed product, or human clinical development record was identified. ([aacrjournals.org](https://aacrjournals.org/cancerres/article/78/13_Supplement/2900/627388/Abstract-2900-Evaluation-of-endoglin-CD105-as-a))
- Other names
- huRH105 + DGN549anti-endoglin-DGN549 ADCanti-endoglin-DGN-549 ADCanti-endoglin-DGN 549 ADC
02
Targets
ENG (Integrin Beta 6)
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