Drug intelligence / Profile preview

Huzhang Jiedu Keli

Development stage: Unknown
Lead developer: Shanghai Municipal Hospital of Traditional Chinese Medicine
Modality: Small Molecules
Administration: Oral

Overview

Huzhang Jiedu Keli (虎杖解毒颗粒) is a Traditional Chinese Medicine (TCM) formulation primarily composed of *Polygonum cuspidatum* (Huzhang). It is recognized for its potent anti-inflammatory and antiviral properties, largely attributed to its high content of resveratrol and polydatin. The drug was notably included in Chinese clinical guidelines as a recommended treatment for COVID-19 to manage inflammatory responses and viral symptoms. Beyond its use in infectious diseases, Huzhang Jiedu Keli has been investigated as an adjuvant therapy in oncology, specifically for its potential to modulate the ecological niche microenvironment in patients with liver metastasis from colorectal cancer. It is typically administered orally in a granule form.

Other names: 虎杖解毒颗粒Polygonum Cuspidatum Detoxification GranulesHuzhang Jiedu Granules

Targets

NF-κBTNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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