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Huzhang Tongfeng
- Development stage
- Unknown
- Lead developer
- Yueyang Hospital of Integrated Traditional Chinese and Western Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Huzhang Tongfeng is a Traditional Chinese Medicine (TCM) formulation, typically administered as granules, developed for the treatment of acute gouty arthritis. It is based on the therapeutic principle of clearing heat, removing dampness, and dredging collaterals (Qin-Re Li-Shi Tong-Luo). The formulation's primary component is *Polygonum cuspidatum* (Huzhang), which is recognized for its anti-inflammatory and analgesic properties, often attributed to active compounds such as resveratrol and emodin. Clinical evaluation, primarily conducted by the Yueyang Integrated Traditional Chinese and Western Medicine Hospital, focuses on the formulation's ability to alleviate joint pain, swelling, and dysfunction associated with gout flares while potentially lowering serum uric acid levels.
- Brand names
- Huzhang Tongfeng GranuleHZTF
- Other names
- Huzhang Tongfeng granulesQin-Re Li-Shi Tong-Luo granules
02
Targets
ALOX12 (Arachidonate 12-lipoxygenase, 12S type)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)CCN1 (Cellular communication network factor 5)IL-6 (Interleukin 6)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)TNFA (Tumor necrosis factor alpha (soluble))ADRB3 (β3)ALOX5 (Arachidonate 5-lipoxygenase)FYN (Proto-oncogene tyrosine-protein kinase Fyn)RELA (Nuclear Factor Kappa B Subunit p65)PIK3R1 (Phosphatidylinositol 4-phosphate 3-kinase regulatory subunit alpha)PIK3CA (Phosphoinositide 3-kinase alpha)
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