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HY-2-15

Development stage: Preclinical
Lead developer: University of Pennsylvania
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

HY-2-15 is a novel small molecule radioligand developed for the detection and imaging of alpha-synuclein (α-syn) aggregates, which are pathological hallmarks of synucleinopathies. It specifically targets a binding site designated as Site 9 on α-synuclein fibrils. Research conducted at the University of Pennsylvania indicates that HY-2-15 exhibits a unique selectivity profile; in human post-mortem brain tissue autoradiography, it binds significantly to α-syn inclusions in Multiple System Atrophy (MSA) samples but shows minimal binding in Parkinson's disease (PD) or Dementia with Lewy Bodies (DLB) tissues. This specificity suggests that HY-2-15 could serve as a specialized diagnostic tool to differentiate MSA from other Parkinsonian disorders and to monitor disease progression in clinical settings.

Other names: [3H]HY-2-15

Targets

aggregated α-syn (Alpha-synuclein (α-syn))Tau aggregates (Microtubule-associated protein tau (pathological form))

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