hyaluronan-oxime hydrogel

Hyaluronan-oxime hydrogel is a biocompatible, in situ gelling polymer system designed for the sustained and localized delivery of therapeutic agents. Formed through a chemoselective oxime ligation between functionalized hyaluronic acid derivatives, the hydrogel creates a stable scaffold upon injection. In the context of ophthalmology, it has been utilized to encapsulate colloidal drug aggregates, such as timolol prodrugs, for the long-term management of glaucoma. This delivery system allows for a significant extension of drug release—maintaining reduced intraocular pressure for several weeks—while simultaneously reducing systemic exposure and potential side effects compared to traditional aqueous formulations.

Other names

HA-oxime hydrogelhyaluronic acid-oxime hydrogel