Drug intelligence / Profile preview

hyaluronan thiomer implant

Development stage
Unknown
Lead developer
Croma-Pharma
Modality
Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
Administration
Implant (intra-articular), Implant (intraocular), Topical (ophthalmic), Surgical Implantation (as Matrix/gel Filler)
01

Overview

**Hyaluronan thiomer implant** is a biodegradable implant comprising hyaluronan (also called hyaluronic acid) chemically modified with thiol groups, developed for use as a scaffold or gel to facilitate tissue repair, particularly in articular cartilage and ophthalmic applications. The thiolated modification permits inter- and intramolecular disulfide bond formation, resulting in 3D stabilization and prolonged retention at the administration site. The implant may be used alone or as a matrix/gel composite and is under investigation for various applications such as cartilage regeneration, osteochondral defect repair, and as an adjunct for ocular surgeries. Preclinical studies suggest the material supports tissue repair without significant immune reaction. The construct is designed for *in situ* biodegradation and biocompatibility[1][3][5].

Other names
hyaluronan thiomer gelhyaluronan thiomer matrixhyaluronic acid-thiomerHA-thiomer
02

Targets

CD44 (CD44 antigen)MUC (Mucin family)

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