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hyaluronic acid + carboxymethylcellulose
- Development stage
- Phase 4
- Lead developer
- Sanofi
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Surgical Implant, Topical, Ophthalmic
01
Overview
Hyaluronic acid + carboxymethylcellulose is a combination of two viscoelastic polymers used primarily in ophthalmic and surgical applications. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that provides significant hydration and promotes ocular surface healing, while carboxymethylcellulose (CMC) is a cellulose derivative that enhances viscosity and stabilizes the tear film. In ophthalmic formulations, such as **Optive Fusion**, the combination acts synergistically to provide osmoprotection and relief for moderate to severe dry eye disease. In surgical contexts, the combination is formulated as a bioresorbable membrane (e.g., **Seprafilm**) that serves as a physical barrier to separate internal tissues and reduce the incidence of postoperative adhesions following abdominal or pelvic surgery.
- Brand names
- Optive FusionSeprafilmOptive Advanced
- Other names
- sodium hyaluronate + carboxymethylcellulose sodiumHA-CMCO/CMC/HA
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