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hyaluronic acid + clodronate + collagen

Development stage: Unknown
Lead developer: Abiogen
Modality: Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration: Intraarticular

Overview

Hyaluronic acid + clodronate + collagen is an intra-articular combination product under development by Abiogen Pharma for the treatment of osteoarthritis. This formulation leverages the synergistic effects of its three components: hyaluronic acid provides viscosupplementation and restores the rheological properties of synovial fluid; clodronate, a non-nitrogenous bisphosphonate, exerts antiresorptive, anti-inflammatory, and analgesic effects by modulating bone metabolism and inhibiting inflammatory mediators; and collagen provides structural support and promotes joint tissue integrity. The product is currently in advanced clinical development, specifically Phase 3, aiming to provide both symptomatic relief and potential structural benefits for patients with degenerative joint disease.

Other names: hyaluronic acid + clodronate + collagen-Abiogan-combination product-intra-articular formulation-intra-articular-osteoarthritisHyaluronic acid intra-articular formulations combined with Clodronate and CollagenHA + clodronate + collagen (Abiogen)

Targets

SLC25A5 (ADP/ATP translocase 2)CD44 (CD44 antigen)

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