hyaluronic acid + pantothenic acid

Hyaluronic acid + pantothenic acid (often formulated using its stable provitamin form, panthenol or dexpanthenol) is a synergistic topical combination widely utilized in dermatological, cosmetic, and medical device formulations to promote skin hydration, barrier repair, and wound healing. Hyaluronic acid, a naturally occurring glycosaminoglycan, acts as a powerful humectant that binds water to plump the skin and interacts with the CD44 receptor to stimulate epidermal regeneration. Pantothenic acid, converted from topically applied panthenol, serves as a key precursor for coenzyme A (CoA) biosynthesis, which is essential for lipid synthesis, fibroblast proliferation, and maintaining stratum corneum integrity. Together, this combination accelerates re-epithelialization, reduces transepidermal water loss (TEWL), and mitigates cellular senescence, making it a staple in anti-aging and post-procedure skin recovery regimens.

Brand names

Cellex-C Hydra 5 B-ComplexLa Roche-Posay Hyalu B5 SerumSkinCeuticals Hydrating B5 GelThe Ordinary Hyaluronic Acid 2% + B5

Other names

Capsule HA:B5Capsule HA-B5hyaluronic acid + dexpanthenolhyaluronic acid + panthenolhyaluronic acid + vitamin B5sodium hyaluronate + dexpanthenolsodium hyaluronate + panthenolsodium hyaluronate + pantothenic acidsodium hyaluronate + vitamin B5