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hyaluronic acid + platelet rich plasma
- Development stage
- Unknown
- Lead developer
- University of Karachi
- Modality
- Cell Therapies
- Administration
- Intraarticular
01
Overview
This combination therapy consists of **Hyaluronic Acid (HA)** and **Platelet-Rich Plasma (PRP)**, which is being evaluated for the treatment of knee osteoarthritis. Hyaluronic acid acts as a viscosupplement, providing mechanical lubrication and shock absorption within the joint to compensate for the loss of synovial fluid quality. Platelet-Rich Plasma is an autologous blood product containing a high concentration of platelets that, upon activation, release various growth factors (such as TGF-β, PDGF, and VEGF) and cytokines. These factors promote tissue repair, stimulate chondrocyte proliferation, and modulate the inflammatory environment of the joint. The combination is hypothesized to have a synergistic effect, where HA improves the joint's physical environment while PRP stimulates biological regenerative processes. A specific study by the **University of Karachi** (NCT04133103) has investigated this combination in patients with Grade II-III knee osteoarthritis.
- Other names
- HA + PRPHyaluronic Acid and Platelet rich plasma
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