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hyaluronic acid + silver sulfadiazine
- Development stage
- Unknown
- Lead developer
- Fidia Farmaceutici
- Modality
- Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems
- Administration
- Topical
01
Overview
A topical pharmaceutical combination of hyaluronic acid and silver sulfadiazine used primarily for the treatment and prevention of wound infections in burns and chronic wounds. Hyaluronic acid is a naturally occurring glycosaminoglycan that promotes tissue repair by supporting cell migration, proliferation, granulation tissue formation, and modulating inflammation. Silver sulfadiazine is a sulfonamide antibiotic with broad-spectrum antimicrobial activity against gram-positive bacteria, gram-negative bacteria, and some fungi; it acts by releasing silver ions that disrupt microbial cell walls and DNA. The combination leverages the regenerative properties of hyaluronic acid with the antimicrobial effects of silver sulfadiazine to accelerate healing while reducing infection risk. This fixed-dose product is indicated for second-degree burns, chronic ulcers (including diabetic ulcers), post-traumatic wounds, superficial abrasions, parastomal ulcerations, and other complicated skin lesions at risk of infection[1][2][4][8].
- Brand names
- Connettivina PlusHYALO4 Control CreamHYALO-4 Control CreamHYALO 4 Control Cream
- Other names
- HA-SSDHA+SSDhyaluronic acid and silver sulfadiazine combination cream
02
Targets
PGN (Peptidoglycan)DHPS (Dihydropteroate synthase)
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