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hyaluronic acid-17β-estradiol conjugate

Development stage: Preclinical
Lead developer: Holy Stone Healthcare
Modality: Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration: Intravenous

Overview

Hyaluronic acid-17β-estradiol conjugate is an investigational **polymer-drug conjugate** in which 17β-estradiol is covalently linked to sodium hyaluronate. The conjugate was developed as a brain-directed, prolonged-release estradiol delivery approach intended to cross the blood-brain barrier and mitigate systemic adverse effects associated with conventional estrogen supplementation. In ovariohysterectomized rat models of estrogen-deficiency-associated cognitive impairment, intravenous HA-E2 improved spatial learning and memory and increased markers of cholinergic innervation and hippocampal synaptic plasticity. It remains a preclinical research-stage therapeutic and is not an approved medicine.

Other names: HA-E2HA-E-2HA-E 2hyaluronic acid-17β-estradiolhyaluronic acid-conjugated 17β-estradiolhyaluronic acid–17β-estradiol conjugate

Targets

ESR1 (ERα)ESR2 (ERβ)

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