Drug intelligence / Profile preview

hyaluronic acid complex

Development stage
Phase 4
Lead developer
NEW Cyprus Health and Social Sciences University
Administration
Topical
01

Overview

Hyaluronic acid complex is a formulation of hyaluronic acid, a naturally occurring glycosaminoglycan found in the extracellular matrix of connective tissues, skin, and synovial fluid. In clinical settings, such as oral and maxillofacial surgery, hyaluronic acid complex (often administered as a 0.2% gel) is utilized for its anti-inflammatory, analgesic, and tissue-regenerating properties. It helps reduce postoperative pain, edema, and trismus (limited mouth opening) following procedures like mandibular third molar extraction. Hyaluronic acid acts as a ligand that binds to cell surface receptors, primarily CD44 and RHAMM, modulating inflammatory responses, promoting angiogenesis, and accelerating wound healing and tissue repair.

Other names
hyaluronic acidhyaluronic acid 0.2% gelhyaluronic acid gel
02

Targets

AKT (RAC-alpha serine/threonine-protein kinase)CD44 (CD44 antigen)EGFR (Epidermal growth factor receptor)MAPK3 (Mitogen-activated protein kinase 1)FAK (Focal adhesion kinase)HMMRICAM1 (Intercellular Adhesion Molecule 1)TLR4 (Toll-like receptor 4)

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